STUDY PROTOCOL: A MIXED-METHODS STUDY TO EVALUATE WHICH HEALTH VISITING MODELS IN ENGLAND ARE MOST PROMISING FOR MITIGATING THE HARMS OF ADVERSE CHILDHOOD EXPERIENCES

Introduction Exposure to adverse childhood experiences (ACEs) is associated with poorer health outcomes throughout life.In England, health visiting is a long-standing, nationally implemented service that aims to prevent and mitigate the impact of adversity in early childhood, including for children exposed to ACEs.A range of health visiting service

Hyperthermia impairs physical performance and, when prolonged, results in heat stroke or other illnesses.While extensive research has Support investigated the effectiveness of various cooling strategies, including cold water immersion and ice-suit, there has been little work focused on overcoming the cutaneous vasoconstriction response to external

Genetically modified macrophage infusion has been proven to be a novel treatment for cancer.One of the most important processes in macrophage-based therapy is the efficient transfer of genes.HIV-1-derived lentiviruses were widely used as delivery vectors in chimeric antigen receptor T and NK cell construction.While macrophages are relatively refrac

Circular RNAs (circRNAs) are highly stable RNA molecules that are attractive templates for expression of therapeutic proteins and non-coding RNAs.In eukaryotes, circRNAs are primarily generated by the spliceosome through backsplicing.Here, we interrogate different molecular elements including intron type and length, Alu repeats, internal ribosome e